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J Child Neurol (2003) 18:1138.10.1177/08830738030180020501 22 JamesSJMelnykSJerniganSClevesMAHalstedCHWongDHet alMetabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

While many of the key regulators of this pathway remain largely unknown, recent studies have identified glutathione peroxidases, particularly glutathione peroxidase 4 (GPX4), as antioxidant enzymes that can prevent lipid peroxidation using reduced glutathione (GSH) as a co-factor 9,10