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In the SURMOUNT5 trial, participants lost an average of 20.2 % of their baseline body weight over 72 weeks with tirzepatide, with a greater proportion achieving weight-loss thresholds of 1525 % compared with semaglutide

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Adenosine is known to mediate the intoxicating effect of alcohol [71-75], and A 2A R inhibition may increase reward-seeking behaviors when subjects are introduced to addictive substances or activities