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(A) Oral glucose tolerance test of STZ-induced KM mice, 6 weeks after STZ injection (n = 15)

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Strategies that may reduce side effects include: Eating smaller meals Avoiding high-fat or heavy foods Maintaining hydration Following the prescribed titration schedule Serious but Rare Risks Serious side effects are uncommon but may include: Pancreatitis Gallbladder disease Severe dehydration Kidney complications (often related to dehydration) There is also a boxed warning regarding thyroid C-cell tumors observed in animal studies

Preclinical studies in rodents showed thyroid C-cell tumours, though the relevance to humans remains uncertain