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Panels combining multiple serum markers show improved performance compared to single markers but require further validation

Additionally, when examining immobility per minute, a two-way repeated measures ANOVA showed a significant effect of treatment over time (F(1, 22) = 8.643, p = 0.0076), with semaglutide-treated mice spending significantly less time immobile in minutes 3, 4, and 5 compared to controls (p values of 0.0309, 0.0001, and 0.0131, respectively)

Moreover, 8-OHdG concentrations were found to be much higher in the CSF of PD patients than in controls, which could further increase as the course of the disease prolonged (Isobe et al., 2010)

Besides the fact that most of these peptides dont have FDA approval, what concerns do many doctors have about them