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These multifaceted mechanisms underscore the relevance of GLP-1 in managing metabolic, cardiovascular, and neurodegenerative disorders ( The cloning and characterization of the GLP-1 receptor (GLP-1R) marked a key milestone in understanding GLP-1s mechanisms of action

Patent expirations, generics competition, and a global surge in metabolic drug development could dramatically increase the number of trials targeting obesity and metabolic disease

To our knowledge, no study assessed the potential of abuse of these medications anecdotally reported in anorexia or bulimia nervosa, which would require further investigation

Tirzepatide has been evaluated for long-term use in clinical trials, with most users experiencing positive results without significant safety concerns