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Patients with significant bile acid diarrhea, severe pancreatic insufficiency, or active pancreatitis may face higher risk and warrant closer monitoring or alternative strategies

The two main signaling cascades started by IGF1 LR3 receptor binding are the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the mitogen-started protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway