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doi: 10.1016/j.cryobiol.2009.09.012, 39

N-acetyl cysteine protects the liver and kidneys and improves detoxification pathways, in addition to having anti-inflammatory effects

Mechanistically, cytoplasmic hypoxia-inducible factors (HIFs) stabilize in response to hypoxia and translocate to the nucleus to induce the transcription of adenosine receptors

The included trials also varied substantially in their populations, treatments and study designs, which may have affected the precision of the estimates

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