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This is achieved through stimulation of pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons and the indirect inhibition of the orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) axis via GABAergic mechanisms.18 The partial permeability of the bloodbrain barrier in circumventricular structures and the arcuate nucleus, alongside potential GLP-1R-dependent involvement of tanycytes, facilitates the access of both LIRA and SEMA to brain regions that are essential in the regulation of food intake
It helps the body produce insulin more effectively and controls blood sugar levels while also reducing appetite, often leading to weight loss
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