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However, accumulating evidence has identified additional GI complications, including cholelithiasis, cholecystitis, gastroparesis, and bowel obstruction, which may warrant caution in susceptible individuals

Small molecules, as the phosphodiesterase-4 inhibitor apremilast, approved for the treatment of adults with moderate-to-severe plaque psoriasis and/or psoriatic arthritis, have demonstrated a broad anti-inflammatory activity, which may influence metabolism (17, 78)

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Our goal is to move beyond the hype and facilitate a critical evaluation of the current scientific landscape, empowering informed decision-making in practice