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When added to insulin in the setting of inadequately controlled type 2 diabetes, oral semaglutide was superior to placebo at improving glycemic control and reducing body weight over 26 weeks, with significant differences also seen at 52 weeks, and with no increase in the risk of hypoglycemia, Bernard Zinman , MD, a senior investigator at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, and colleagues wrote

As tirzepatide produces weight loss and potentially lowers blood pressure on its own, your provider may consider adjusting or discontinuing your diuretic

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