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While these findings are encouraging, the absence of randomization and the inclusion of multiple active ingredients make it difficult to attribute the observed effects specifically to the proposed triad

TP53 mutations are frequent in malignant NF1 tumors

The immunological system is also a regulator of lipid deposits through macrolipophagy, where there is phagocytosis of the endo- and exogenous lipids at the hepatic level [26]