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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

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Sulforaphane pre-treatment protects from oxidative damage, reducing 8-oxo-dG positive cells to the level observed in control animals and preventing loss of parvalbumin-positive cells, thereby preventing schizophrenia-like behaviors (Shirai et al., 2015)