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13 As the first orally administered GLP-1 RA, oral semaglutide provides an option for patients unwilling or unable to self-inject

The most common adverse events included nausea, affecting 38.1% to 43.2% of treated patients compared to 10.7% with placebo, diarrhea in 33.1% to 34.7% versus 13.4% with placebo, and constipation in 21.8% to 25% compared to 8.7% with placebo

Some patients experience mild fatigue during the first two weeks

Originally developed as a treatment for diabetes, Semaglutide was later discovered to be highly effective for weight management, which led to its approval for obesity treatment under the brand name Wegovy