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For lupus patients, who often have chronically elevated IL-6 and TNF-alpha levels, these findings suggest tirzepatide may offer anti-inflammatory benefits that complement rather than conflict with existing immunomodulatory therapy

Recent regulatory guidance underscores the risks associated with compounding GLP-1s using additives such as B12 or glycine

Basically, the LH contains two distinct neuronal cell populations that regulate feeding behaviour: containing hypocretin/orexin [57, 58] and a melanin-concentrating hormone (MCH) [59] (Figure 2)