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NAD+ and mitochondrial biogenesis NAD+ works as a vital cofactor that changes metabolism, activates sirtuins, and keeps mitochondrial fitness through mechanisms like the mitochondrial unfolded protein response

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Caffeine is metabolized more slowly in pregnant individuals, with a half-life of about 15 hours in pregnant individuals compared to about five hours in nonpregnant women

Patients with certain medical conditions should exercise caution: those with Leber's hereditary optic neuropathy (a rare genetic condition) may experience optic nerve damage with high-dose cyanocobalamin