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Excessive burden of ROS, failure of clearance mechanisms and even lack of antioxidants may lead to the accumulation of ROS and to oxidative stress [40], which are associated with genetic damage and breast cancer onset [61,62,63,64,65]

5.3.2.2 Time trends Between 1982 and 1984 the prevalence of bronchial hyper-responsiveness assessed by histamine challenge test among 2363 Australian children was 17.9% (Salome et al., 1987)

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