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Given that the SAM is the universal methyl donor for methylation of substrates including proteins, nucleotide acids and lipids, the NNMT induced methyl sink in the form of MNA impairs the genome methylation

uncovered that hsa-miR-1301-3p suppressed the expression of alcohol dehydrogenase 6 (class V) (ADH6), aldehyde dehydrogenase 5 family member A1 (ALDH5A1), and aldehyde dehydrogenase 8 family member A1 (ALDH8A1) within the alcohol oxidation pathway, effectively dampening alcohol-induced oxidative stress and mitigating liver damage (Wang et al., 2020)

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Treatment Iron chelation treatment Despite the novel comprehension of the pathophysiology of -thalassemia, iron chelation therapy still remains the most efficacious approach for reducing the morbidity and mortality associated with iron overload in patients with NTDT and TDT (118)