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Suppression of high glucose-induced cell proliferation in HepG2 cell line model by lutein was linked to increased expression of high glucose-mediated repressed HO-1 and prevention of hyperglycemia-mediated elevated ROS, but it was not associated with the induction of apoptosis

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HMGB1-mediated macrophage inflammation requires the receptor for advanced glycation end products (101, 102)

The LC/MS portion of the platform was based on a Surveyor HPLC and a Thermo-Finnigan LTQ Fmass spectrometer (Thermo scientific, Waltham, Massachusettes, USA), which consisted of an electrospray ionization (ESI) source and linear ion-trap (LIT) mass analyzer