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Over time, that pooling puts sustained pressure on the vein walls and surrounding tissue, producing the symptoms most people recognize: twisted, rope-like varicose veins, smaller spider veins, persistent leg swelling, aching, skin discoloration, and in advanced cases, open sores called venous ulcers

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Diarrhea can be managed by drinking plenty of water and avoiding dairy products and high-fiber foods until symptoms go away

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These effects are seen even outside of diabetes control.[ref] Related article: APOE genotype and Alzheimers risk Cardiovascular disease benefits: A number of studies have shown that GLP-1 RAs provide benefits for reducing cardiovascular disease

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