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In cardiovascular system, LC and TMZ are not only influence cardiomyocytes but also may influence other systems working followed by indirectly feedback to cardiomyocytes

Unlike genomics or proteomics, which survey upstream regulatory layers, metabolomics provides an immediate snapshot of biochemical activity and cellular physiology (Kwon et al., 2023)

Exercise, as a vital non-pharmacological intervention, holds great promise in preventing, treating, and rehabilitating NDDs, as it can directly or indirectly suppress ferroptosis and mitigate NDD progression by regulating iron metabolism, oxidative stress, and exerkines expression

Compared to the control group, Diazinon significantly increased IL1B levels