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Tesofensine administration on a diet-induced obesity model This study investigated the effectiveness of tesofensine in treating obesity using a diet-induced obesity model [20, 21]

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Moreover, vascular endothelial cells in the breast cancer microenvironment release several miRNAs ( miR-142-5p , miR-183-5p , and miR-222-3p ) that are transported through extracellular vesicles, and subsequently regulate macrophage remodeling and promote macrophage polarization toward the M2 phenotype 73 ( Figure 3H )