long term side effects from glp 1 glp-1 What are experts learning about the long-term of medications? glp 1 negative side effects

Clinical trials of FDA-approved semaglutide and tirzepatide show the difference clearly: Semaglutide patients lose about 15% of total body weight Tirzepatide patients lose approximately 21% Both medications can cause mild gastrointestinal side effects, but tirzepatide is often better tolerated, with many patients reporting fewer symptoms

Animal studies show reduced binge-eating behavior by 50%

Acknowledgements Support for VA and Centers for Medicare and Medicaid Services data is provided by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Health Services Research and Development, VA Information Resource Center (Project Number/Data Use Agreement ID Al-Aly-01-A-1)

Considering the relationship between GLP-1 signaling and behavioral symptoms characteristic of depression, it was shown that intracerebroventricular ( icv ) administration of both GLP-1 and exendin-4 enhances associative and spatial learning, while these effects are inhibited by a GLP-1R antagonist