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By comparing the results of untargeted metabolomics analyses of serum samples of surviving patients, deceased patients and healthy controls, the bile acids (BAs) chenodeoxycholic acid (CDCA), GCDCA, TCDCA and taurodeoxycholic acid (TDCA) were found to be upregulated in the surviving patients

P-gp is an ATP-dependent efflux pump located in the cell membrane that, among other drugs, transports Tac back into the intestinal lumen

Moreover, the unlimited proliferation and immune evasion properties of CSCs contribute to drug resistance and tumor recurrence in patients with OC, making OCSCs a major factor in these clinical challenges (64)

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