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However, we must interpret these findings with caution, explicitly acknowledging the significant heterogeneity in study design, patient cohorts, and choice of comparator agents that characterizes the current body of literature

Hopefully, imminent results from studies such as the REMODEL trial (52), in which detailed molecular studies are being performed in human renal biopsies from subjects who have received semaglutide, will further define the effect of these agents on macrophage biology

Clinically known as glucagon-like peptide 1 agonists , GLP-1s were originally developed to treat diabetes

They need to be small, gentle, familiar, and steady