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This trajectory mirrors aspects of human hepatic ontogeny, where hepatoblasts differentiate into functional hepatocytes and cholangiocytes before a subsequent phase involving mesenchymal cell expansion 32
Nausea may occur early, improve with continued treatment, and sometimes become noticeable again after a clinician-directed dose increase
Most GI events occurred during dose escalation and resolved within 4 to 8 weeks of reaching each new dose level
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