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Importantly, neither agent prevented ongoing AGE formation, consistent with their modes of action: Fertilix quenches downstream ROS, whereas ALT-711 cleaves existing AGE cross-links but cannot block their dietary generation 87

In addition to the TRPA1 channel, involvement of cysteine groups on the activation of TRPM2 channels in transfected human embryonic kidney (HEK-293) cells was reported (Mei et al., 2006)