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Goepfert RP, Zafereo ME

Other intranasal preparations being explored in Parkinsons include dopamine, one using gene therapy, a vitamin E loaded naringenin, stem cells, glial cell-derived neurotrophic factor (GDNF), carnosine, BDNF, intranasal insulin, rotigotine, and estradiol

If the diagnosis is secondary constipation, efforts should be made to treat the cause (eg, an underlying medical condition or medication side effect), but it may still be helpful for these patients to increase dietary fiber and fluids and to engage in regular physical activity (Rao 2014)

Among these additions, levocarnitine has perhaps the most mechanistically coherent rationale for inclusion