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Aug 11 2024 Van Tin et al., Cells, doi:10.3390/cells13161331 Spike Protein of SARS-CoV-2 Activates Cardiac Fibrogenesis through NLRP3 Inflammasomes and NF-B Signaling In vitro study showing that the SARS-CoV-2 spike protein can activate cardiac fibroblasts through ACE2-dependent mechanisms, leading to cardiac fibrosis via the NLRP3 inflammasome and NF-B signaling pathways

It has the characteristics of fewer side effects and can quickly concentrate in the brain tissue through the BBB (Palmer et al., 1994)