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These include severe chest pain, sudden shortness of breath, signs of stroke such as sudden weakness or slurred speech, uncontrolled bleeding, sudden severe abdominal pain, or symptoms of severe allergic reaction like difficulty breathing and throat swelling

Melatonin tended to exert stronger protective effects on certain parameters, particularly in preserving AMH levels, attenuating fibrosis, and reducing Caspase-3 and NF-B expression, although the differences between Mel+CARB and GSH+CARB groups were not statistically significant in all comparisons

Although uterine expression levels of estrogen receptor , G protein-coupled estrogen receptor, and steroid synthase were upregulated in the high-dose group, the decreased expression of connexin 43 and alkaline phosphatase as well as the increased expression of insulin-like growth factor-binding protein three and monoamine oxidase were consistent with decreased estrogen signaling and lower uterine weights

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