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Vigorous shaking denatures the peptide

2024 Oct 3 [cited 2025 Sep 5];17(10):1322

For mild itching or sensitivity , over-the-counter remedies may provide relief: Emollient creams or ointments applied liberally Antihistamines (such as cetirizine or loratadine) may help if itching is troublesomenon-sedating types are generally preferred for daytime use, but consult your pharmacist first as some antihistamines can cause drowsiness Cool compresses applied to affected areas for short periods Avoid potential irritants including: New skincare products, cosmetics, or laundry detergents Excessive scratching, which can damage skin and increase infection risk Self-medicating with topical steroids without medical advice If you experience persistent vomiting or diarrhoea while taking Rybelsus, contact your healthcare provider promptly as dehydration can worsen skin problems and affect your overall health

But they come with significant drawbacks: high cost, injection site reactions, increased infection risk due to immune suppression, and the development of anti-drug antibodies over time that can reduce efficacy