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Control mice grasped and rotated seeds efficiently, exposing intact kernels, whereas mice with arthritogenic autoantibodies at all phases failed to maintain grip and adopted inefficient alternative strategies, leading to partial peeling and failure to expose intact kernels (Fig

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doi: 10.3390/nu11010039 13

Conversely, nicotine may exert paradoxical inhibitory effects by activating immune pathways and inducing apoptosis, such as through stimulation of immature dendritic cells via PI3K/Akt signaling and modulation of caspase-3 and Cyclin B1 expression through 7-nAChR signaling [36]