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Individuals with underlying liver disease, compromised immune systems, or other chronic conditions may face undocumented risks that the current evidence base is not sufficient to characterize

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[40] demonstrated in vitro that a decrease in endogenous N/OFQ, or the absence of its receptor, results in an increase in capsaicin-induced bronchoconstriction, indicating the ability of this neuropeptide to modulate bronchoconstriction by affecting sensory fibers

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