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At 26 weeks, changes in apoC-III, rather than body weight, were the most accurate predictors of changes in triglyceride levels with tirzepatide, accounting for up to 22.9% of the variability observed.Treatment with tirzepatide demonstrated a dose-dependent decrease in apoC-III and apoB levels, as well as a reduction in the number of large TRLP and small LDLP

In response to ingestion of glucose or a mixed meal and the resulting hyperinsulinemia and hyperglycemia, the fasting liver shifts from net output to net uptake of glucose

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X., Zhen, X., Wang, S., You, C., Nie, J., Zhou, H