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Core Evid

5-12 The most common patient-reported adverse effects (AEs) associated with GLP-1 RAs and dual GIP/GLP-1 RAs are gastrointestinal (GI) in nature and may include abdominal pain, constipation, diarrhea, nausea, and vomiting

"This concept could reshape how GLP-1RAs are prescribed across different disease states." The field is evolving in four directions at once: oral formulations, multi-agonist combinations, muscle preservation strategies, and expansion into disease areas beyond metabolic medicine

Dual Agonists Under Investigation Tirzepatide (Mounjaro) was approved by the FDA on May 13, 2022 for the treatment of type 2 diabetes in adults, making it the first and only GIP/GLP-1 receptor agonist