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recently showed that direct GPx4 overexpression in the cellular models (A549, H460 and H1299 and H23) of non-small cell lung carcinoma (NSCLC) prevented the radiation-induced lipid peroxidation and, in turn, contributed to radioresistance by blocking the ferroptosis mode of cell death [56]

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Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse

Initial randomized clinical trials indicate possible reductions in craving and substance intake, though findings are mixed and ongoing studies are needed to determine safety and efficacy in patients with alcohol and other substance use disorders