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These studies indicated that in response to oxidative stress, there is not only an increase in expression of both PA28 and PA28 over the subsequent 24 h, but also enhanced capacity of the 20S proteasome to selectively remove oxidative damaged proteins (Pickering and Davies, 2012b)

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Findings from the FLOW trial, the first-ever dedicated kidney outcomes trial with a glucagon-like peptide-1 (GLP-1) receptor agonist, demonstrated that semaglutide slowed progression of kidney disease in people with type 2 diabetes and improved both kidney outcomes and cardiovascular mortality