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These findings align with previous research indicating that hypoxia promotes the proliferation and colony formation of USCs cultured on collagen type I scaffolds, primarily by increasing the proportion of cells in the S phase of the cell cycle (Kheirandish et al., 2017

These observations have sustained interest in melanocortin pathway modulation as a framework for understanding individual variability in skin cancer risk and for exploring photoprotective signaling mechanisms relevant to prevention-oriented research [29,30]

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