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Loading dose should be infused slowly over 60 minutes.8 hours: 30 g or 5 x 30 mL (20%) vials24 hours: 54 g or 9 x 30 mL (20%) vialsWithin 1 hourNaloxone/ NarcanOpioid overdoseUse small initial dose to avoid abrupt awakening/withdrawal8 hours: 20 mg or 50 x 0.4 mg/2 mL amps or 2 x 10 mg/10 mL vials24 hours: 40 mg or 4 x 10 mg/mL vialsImmediate emergency departmentOctreotide acetate/ SandostatinOral sulfonylurea poisoning and meglitinide poisoningAvoid long-acting depot products8 hours: 200 mcg or 2 x 1 mL (0.1 mg/mL) amps24 hours: 1000 mcg or 1 x 5 mL (0.2 mg/mL) multidose vialWithin 1 hourPhysostigmine/ Antilirium(When available)Anticholinergic poisoning, especially antimuscarinic deliriumAdminister at low dose (0.5 mg) and slowly, over 2-5 minutes to avoid severe adverse reactions including bradycardia, asystole and seizures (Contraindicated in TCA or similar poisoning with widened QRS intervals)8 and 24 hours: 4 mg or 2 x 2 mL (1 mg/mL) amps(When available)Immediate emergency departmentPotassium IodideThyroid radioiodine protectionHighest risk groups for radioiodine-induced cancer are infants, children and pregnant and nursing females

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