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It should also be noted that these trials predominantly included relatively healthy older participants, as individuals with potential comorbidities such as cardiovascular or renal diseases were often excluded [12, 34]
This includes that exercise may interfere with intestinal microorganisms and metabolites, and then inhibit the activation of inflammatory signaling pathways such as NLRP, thereby hindering the progression of related diseases (Quiroga et al., 2020)
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