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Then, during the thawing process, you can get pockets of high solute concentration that further stress the peptide

In kidney transplant recipients, 38% have diabetes pre-transplant, 4 and 4% to 25% develop post-transplant diabetes mellitus (PTDM)

This aligns with previous reports that myostatin mutations across species did not cause long-term AEs and with previous studies investigating apitegromab in individuals with SMA 9,14,16,19