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Neuromodulatory effects of anti-diabetes medications: a mechanistic review

Truncation studies showed that the membrane proximal 61 amino acids of GP130 are sufficient for signal transduction (68), and later it was shown for GHR that the membrane proximal 20 residues (which includes the Box1 motif) of the ICD is sufficient for JAK2 binding, but not sufficient for GH-induced activation of JAK2 (69)

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It also notes that as GLP-1 therapy drives weight loss, thyroid hormone requirements may change, and that any change should follow TSH trends rather than weight alone