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HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67

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For ongoing prevention, patients should aim for gradual fibre intake (2530g daily), adequate hydration (at least 1.52 litres of fluid daily, unless advised to restrict fluids due to heart or kidney conditions), and smaller, more frequent meals to manage both conditions effectively