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Whilst GLP-1 receptor activation can exert multiple direct neuroprotective effects, the protective influence of GLP-1 receptor agonists may occur indirectly through the restoration of the dysfunctional insulin signaling associated with neurodegenerative disease

Acta Neuropsychiatrica, 32 , 218225

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However, we now know that when blood sugar levels get under control, the GIP receptor starts to work more effectively again, and as this is a very strong receptor, there is a good case for developing therapies that target the GLP-1 receptor and the GIP receptor simultaneously