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In conclusion, mitochondria, as centers of energy metabolism, play a critical role in the transcriptional and epigenetic regulation of T cell exhaustion by linking metabolic adaptation to epigenetic regulation (Fig

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Viral theory Several studies have depicted a strong association between vitiligo and hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in vitiligo patients (Akbayir et al

Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses