The two coronavirus sites with exact P4-P1 matches to GCLC are those at either end of nsp5, i.e., M pro itself, which have the highest catalytic efficiency for cleavage of any of the viral M pro targets (100 and 41%)
Building your personalised GHK-Cu protocol in Mumbai A workable GHK-Cu protocol comes from six clean steps: Define the goal - skin, hair, healing, longevity or a combination Choose the route - injectable, topical, oral, or a combination Set the starting dose - conservative end of the range for your goal Set the schedule - daily, 5-on/2-off, or 3/week
Lifespan extension in animal studies Rodent studies (most extensive data): Mice lifespan increased 20-42% with Epithalon Rats showed 12-25% lifespan extension Both maximum lifespan and median lifespan increased Healthspan (healthy years) improved even more Similar to effects seen with caloric restriction but without dietary limitation Study examples: Mechanisms of lifespan extension: Telomere preservation preventing cellular senescence Reduced oxidative damage to tissues Improved immune function preventing infections Better hormone regulation (pineal, reproductive) Reduced age-related diseases (cancer, cardiovascular) Human lifespan effects (theoretical): No completed human lifespan studies (require decades) If similar extension: 20% of 80-year lifespan = 16 additional years More realistically: Healthspan improvement more achievable than lifespan Quality of life in later years potentially enhanced Similar goals as other longevity interventions Limitations of animal data: Rodents humans (metabolism, telomere biology differ) Controlled lab conditions vs real-world human life Optimal dosing in humans unknown Long-term safety in humans not established Need rigorous human trials for validation Compare to other longevity approaches like growth hormone peptides at SeekPeptides
Martin PM, Roon P, Van Ells TK, Ganapathy V, Smith SB
