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[77] When levodopa and kava are taken together, it has been shown that there is an increased frequency of this "on-off phenomenon"

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USP2 WT transfection promoted TGF1-induced nuclear localization of SMAD3, and increased SMAD3-mediated transcriptional activity, the protein level of TGFBR1 , and the mRNA level of TGF signaling target genes ( COL1A1, COL1A2, SERPINE1 , and SMAD7 ), while USP2 K447R abolished these effects (Fig

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Additionally, nucleic acid-based nanomedicines DCR-MYC, which encapsulates MYC siRNA in lipid nanoparticles, targets and inhibits the expression of the oncogene MYC in HCC

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