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The treatment involved intravenous DSIP administration on five consecutive days, followed by five injections every 48-72 hours

Mechanisms of action The cardiovascular benefits of SGLT2 inhibitors are likely mediated through multiple complementary pathways relevant to heart failure which include osmotic diuresis and natriuresis, which may reduce cardiac preload

de Jong SC, Stehouwer CD, van den Berg M, Kostense PJ, Alders D, Jakobs C, Pals G, and Rauwerda JA (1999b)