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Berberine may cause gastrointestinal symptoms and interact with diabetes medications, increasing hypoglycaemia risk when combined with insulin or sulfonylureas

From a histological point of view, atypical tumor glands, constituted by neoplastic epithelial cells, occur in dense desmoplastic stroma, a proper physical barrier promoting tumor growth and progression and contributing to hamper anti-tumoral response and therapeutics delivery [11,12,13,14]