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The second and the third light activations elicited responses that were similar to the responses observed after the first light activation, though with a mildly lower amplitude, which may be attributed to bleaching of the fluorescent signal (Fig 5A and B)

88 This conclusion was further supported by the demonstration of a dramatic increase in nitrotyrosine staining and liver injury in MnSOD (SOD2) partial knockout mice, 90 as well as the elimination of nitrotyrosine protein adducts and liver injury in animals treated with mitochondrial-targeted SOD mimetics such as Mito-TEMPO 91 and Mito-Q

Additional research is warranted to determine the therapeutic benefits of MCT in patients with AD and to ascertain how APOE-4 status may mediate -HB efficacy

however, the body weights of mice in the DOX and Doxil groups decreased by ~20% after 14 day treatment