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Choi CKK, Zhang L, Choi CHJ

A randomized controlled study that followed 44 normoglycemic children and adolescents with obesity from early puberty to puberty completion demonstrated that, although Metformin improved anthropometric parameters such as BMI z-score, waist circumference and percent body fat, it did not have a beneficial effect on insulin sensitivity or -cell function compared to placebo (193)

But with aging, the immune system fails to clear these cells efficiently, and they accumulate in tissues throughout the body